Activation of the cGAS-STING pathway by NBTXR3 nanoparticles exposed to radiotherapy

AACR, Chicago, Illinois · 2018, Marill J. et al.

Authors

Marill J., Darmon A., Zhang P., Paris S.
Nanobiotix, 60 rue de Wattignies, 75012 Paris, France

Summary

Recent studies reported that radiotherapy could activate the cGAS-STING pathway, which plays a fundamental role in the immune response to cytoplasmic DNA, by activation of the transcriptional factor IRF3, leading to expression of interferon-beta. Moreover, cGAS-STING activation appears to be an important component for tumor resident Antigen-Presenting Cells activation, a crucial step for induction of CD8+ T cell response against tumor derived antigens.

In this study, it was observed the ability of radiotherapy-activated NBTXR3 to increase cGAS-STING pathway response, compared to radiotherapy alone.