Cytotoxic | Nano Publications https://bibliography.nanobiotix.com/fr/ Navigate through all Nanobiotix publications online Tue, 24 May 2022 15:27:22 +0000 fr-FR hourly 1 https://wordpress.org/?v=6.0 https://bibliography.nanobiotix.com/wp-content/uploads/2019/11/cropped-n-icon-512x512-32x32.png Cytotoxic | Nano Publications https://bibliography.nanobiotix.com/fr/ 32 32 2017 – Abstract SITC Conference Maryland – Clinical https://bibliography.nanobiotix.com/fr/2017-abstract-sitc-conference-maryland-clinical/ https://bibliography.nanobiotix.com/fr/2017-abstract-sitc-conference-maryland-clinical/#respond Tue, 07 Nov 2017 06:54:45 +0000 http://bibliography.nanobiotix.com/2017/11/07/2017-abstract-sitc-conference-maryland-clinical/ Soft tissue sarcoma (STS) is a large and heterogeneous group of malignant mesenchymal neoplasms characterized by a strong tendency toward local recurrence and metastatic spreading. Consistently, the immune microenvironment in sarcomas is highly variable. A new class of material with high electron density, hafnium oxide, was designed at the nanoscale to efficiently absorb ionizing radiation […]

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Authors

Galon J.1, Laé M.2, Thariat J.3, Carrere S.4, Papai Z.5, Delannes M.6, Rochaix P.6, Mangel L.7, Hermitte F.8, Sapi Z.9, Tornoczky T.7, Servois V.2, Birtwisle Peyrottes I.3, Tetreau R.4, Château M-C.4, Paris S.10, Brisse H.2, Bonvalot S.2
1 – INSERM, Paris, France
2 – Institut Curie, Paris, France
3 – Centre Antoine Lacassagne, Nice, France
4 – Centre regional de lutte contre le cancer, Paul Lamarque, Montpellier
5 – Medical Centre Hungarian Defences forces, Budapest, Hungary
6 – Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France
7 – Pecs University, Pecs, Hungary
8 – HalioDx, Marseille, France
9 – Semmelweis University, Budapest, Hungary
10 – Nanobiotix, Paris, France

Summary

Background: Soft tissue sarcoma (STS) is a large and heterogeneous group of malignant mesenchymal neoplasms characterized by a strong tendency toward local recurrence and metastatic spreading. Consistently, the immune microenvironment in sarcomas is highly variable. A new class of material with high electron density, hafnium oxide, was designed at the nanoscale to efficiently absorb ionizing radiation from within the tumor cells and augment the dose deposited to a tumor. […]

Material and Methods: Tumor tissues pre- (biopsy) and post-treatment (resection) are collected from patients with locally advanced STS (NCT02379845), who received either HfO2-NP activated by RT or RT alone. Immunohistochemistry and Digital Pathology for immune biomarkers and Pan-Immune gene expression profiling are analyzed.

Results: A significant increase of CD8+ T cells and a marked increase of CD3+ and PD-1 T cells and CD103+ immune cell infiltration post- vs pre-treatment are observed for HfO2-NP + RT while not differences are seen for RT alone (more than 10 patients analyzed in each arm). Functional analysis of genes expression up-regulated in HfO2-NP + RT post- vs pre-treatment shows an enrichment of cytokine activity (IL7, IFNA, IL11, IFNG), adaptive immunity (RAG1, TAP1, TAP2, TBX21, IFNG, LTK, CD37, CD22) and T cell receptor signaling pathway (CD28, CTLA4, CD274, BTLA, TIGIT, CD5, ZAP70) when compared to RT.

Conclusions: Promising results are observed in patients who received HfO2-NP + RT in terms of immune cells infiltration post- vs pre-treatment when compared to RT. […]

The post 2017 – Abstract SITC Conference Maryland – Clinical first appeared on Nano Publications.]]> https://bibliography.nanobiotix.com/fr/2017-abstract-sitc-conference-maryland-clinical/feed/ 0 2017 – AACR Abstract – NBTXR3 combination with cisplatin in vivo and in vitro https://bibliography.nanobiotix.com/fr/2017-aacr-abstract-nbtxr3-combination-with-cisplatin-in-vivo-and-in-vitro/ https://bibliography.nanobiotix.com/fr/2017-aacr-abstract-nbtxr3-combination-with-cisplatin-in-vivo-and-in-vitro/#respond Wed, 01 Mar 2017 10:07:40 +0000 http://localhost:8888/bibliography/?p=778 Combination of NBTXR3 and cisplatin has been evaluated in vitro and in vivo. No specific toxicity was observed for the cells exposed only to NBTXR3. For the combined treatment, a marked and enhanced cell destruction when compared to the single agent. In vivo, NBTXR3 combined with low dose of cisplatin delayed tumor growth when compared to single agent CDDP in combination with RT.

NBTXR3 is intended to be injected in the tumors. Spilling in the circulation may occur during product administration or, as expected, during tumor destruction, leading to steady trapping of NPs in the reticulo-endothelial system (liver and spleen). Clinically, it is unknown whether patients, previously treated with NPs, may show toxic signs when NPs are exposed (activation) to diagnosis imaging (computed tomography(CT)) of the liver.

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Authors

Agnès Pottier1, Sonia Vivet1, Sébastien Paris1, Bo Lu2
1 – Nanobiotix, Paris, France
2 – Thomas Jefferson University, Philadelphia, PA

Summary

Combination of NBTXR3 and cisplatin has been evaluated in vitro and in vivo. No specific toxicity was observed for the cells exposed only to NBTXR3. For the combined treatment, a marked and enhanced cell destruction when compared to the single agent. In vivo, NBTXR3 combined with low dose of cisplatin delayed tumor growth when compared to single agent cisplatin in combination with radiotherapy.

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