Immune Response | Nano Publications https://bibliography.nanobiotix.com/fr/ Navigate through all Nanobiotix publications online Tue, 24 May 2022 09:38:04 +0000 fr-FR hourly 1 https://wordpress.org/?v=6.0 https://bibliography.nanobiotix.com/wp-content/uploads/2019/11/cropped-n-icon-512x512-32x32.png Immune Response | Nano Publications https://bibliography.nanobiotix.com/fr/ 32 32 2018 – OncoRad – NBXTR3 Abscopal Effect https://bibliography.nanobiotix.com/fr/2018-oncorad-nbxtr3-abscopal-effect/ https://bibliography.nanobiotix.com/fr/2018-oncorad-nbxtr3-abscopal-effect/#respond Fri, 05 Oct 2018 08:55:45 +0000 http://bibliography.nanobiotix.com/2018-oncorad-nbxtr3-abscopal-effect/ Recent results of a phase II/III in locally advanced Soft Tissue Sarcoma patients demonstrated clinical benefits of intratumorally injected HfO2-NP activated by radiotherapy compared to radiotherapy alone, validating their first-in-class mode of action. In addition, animal studies have reported that HfO2-NP+RT can induce an abscopal effect, where RT alone cannot. […]

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Authors

Darmon A., Zhang P., Paris S.
Nanobiotix, Paris, France

Summary

Recent results of a phase II/III in locally advanced Soft Tissue Sarcoma patients demonstrated clinical benefits of intratumorally injected HfO2-NP activated by radiotherapy compared to radiotherapy alone, validating their first-in-class mode of action. In addition, animal studies have reported that HfO2-NP+RT can induce an abscopal effect, where RT alone cannot. Here, using a mouse abscopal assay, we measured T cells infiltrates in treated and untreated tumors after HfO2-NP intratumor injection and activation with RT, and their role in the abscopal effect.

These data indicate that the immunogenic conversion of the tumor microenvironment triggered by HfO2-NP+RT generates the abscopal effect by activation of CD8+ T cells. HfO2-NP+RT may potentiate a pro-inflammatory microenvironment appropriate for enabling an anti-tumor immune response. It may act as effective in-situ cancer vaccine and be combined with immunotherapeutic agents across oncology.

The post 2018 – OncoRad – NBXTR3 Abscopal Effect first appeared on Nano Publications.]]> https://bibliography.nanobiotix.com/fr/2018-oncorad-nbxtr3-abscopal-effect/feed/ 0 2018 – AACR – Activation of the cGAS-STING pathway by NBTXR3 https://bibliography.nanobiotix.com/fr/2018-aacr-activation-of-the-cgas-sting-pathway-by-nbtxr3/ https://bibliography.nanobiotix.com/fr/2018-aacr-activation-of-the-cgas-sting-pathway-by-nbtxr3/#respond Mon, 25 Jun 2018 08:07:54 +0000 http://bibliography.nanobiotix.com/2018-aacr-activation-of-the-cgas-sting-pathway-by-nbtxr3/ Recent studies reported that radiotherapy could activate the cGAS-STING pathway, which plays a fundamental role in the immune response to cytoplasmic DNA, by activation of the transcriptional factor IRF3, leading to expression of interferon-beta. Moreover, cGAS-STING activation appears to be an important component for tumor resident Antigen-Presenting Cells activation, a crucial step for induction of CD8+ T cell response against tumor derived antigens. […]

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Authors

Marill J., Darmon A., Zhang P., Paris S.
Nanobiotix, 60 rue de Wattignies, 75012 Paris, France

Summary

Recent studies reported that radiotherapy could activate the cGAS-STING pathway, which plays a fundamental role in the immune response to cytoplasmic DNA, by activation of the transcriptional factor IRF3, leading to expression of interferon-beta. Moreover, cGAS-STING activation appears to be an important component for tumor resident Antigen-Presenting Cells activation, a crucial step for induction of CD8+ T cell response against tumor derived antigens.

In this study, it was observed the ability of radiotherapy-activated NBTXR3 to increase cGAS-STING pathway response, compared to radiotherapy alone.

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