{"id":1506,"date":"2018-08-02T09:47:48","date_gmt":"2018-08-02T08:47:48","guid":{"rendered":"http:\/\/bibliography.nanobiotix.com\/?p=1506"},"modified":"2022-06-01T15:58:00","modified_gmt":"2022-06-01T14:58:00","slug":"2018-asco-nbtxr3-generates-an-anti-tumor-immune-response","status":"publish","type":"post","link":"https:\/\/bibliography.nanobiotix.com\/fr\/2018-asco-nbtxr3-generates-an-anti-tumor-immune-response\/","title":{"rendered":"2018 \u2013 ASCO \u2013 NBTXR3 generates an anti-tumor immune response"},"content":{"rendered":"

[vc_row padding_top=\u00a0\u00bb0″ padding_bottom=\u00a0\u00bb0″ section_container_layout=\u00a0\u00bbfull-width\u00a0\u00bb remove_horizontal_padding=\u00a0\u00bbyes\u00a0\u00bb module_type=\u00a0\u00bbbg-color\u00a0\u00bb gutter_size=\u00a0\u00bbyes\u00a0\u00bb equal_height=\u00a0\u00bbyes\u00a0\u00bb bg_color=\u00a0\u00bb#28282e\u00a0\u00bb][vc_column][vc_row_inner padding_top=\u00a0\u00bb0″ padding_bottom=\u00a0\u00bb0″ gutter_size=\u00a0\u00bbyes\u00a0\u00bb equal_height=\u00a0\u00bbyes\u00a0\u00bb][vc_column_inner column_paddings=\u00a0\u00bb105″ column_position_vertical=\u00a0\u00bbmiddle\u00a0\u00bb column_min_height=\u00a0\u00bb700″ column_min_height_sm=\u00a0\u00bb400″ column_min_height_xs=\u00a0\u00bb350″ module_type=\u00a0\u00bbbg-image\u00a0\u00bb bg_image=\u00a0\u00bb99″ mask_fx=\u00a0\u00bbyes-mask\u00a0\u00bb mask_color_mode=\u00a0\u00bbpalette\u00a0\u00bb mask_bg_color_palette=\u00a0\u00bbmain-mask\u00a0\u00bb animation_fx=\u00a0\u00bbyes-animation\u00a0\u00bb animation_delay=\u00a0\u00bb200″ animation_offset_scroll_down=\u00a0\u00bb90″ width=\u00a0\u00bb1\/2″ animation_in=\u00a0\u00bbfadeInUp\u00a0\u00bb][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][az_box_icons box_icon_title=\u00a0\u00bbAuthors\u00a0\u00bb box_icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_visibility=\u00a0\u00bbyes-icon\u00a0\u00bb icon_type=\u00a0\u00bbfont\u00a0\u00bb icon=\u00a0\u00bbfa fa-edit\u00a0\u00bb icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_size=\u00a0\u00bb50″ box_icon_color=\u00a0\u00bb#ffffff\u00a0\u00bb icon_color=\u00a0\u00bb#ffffff\u00a0\u00bb]Galon J.1<\/span>, La\u00e9 M.2<\/span>, Thariat J.3<\/span>, Carr\u00e8re S.4<\/span>, Papai Z.5<\/span>, Delannes M.6<\/span>, Sargos P.7<\/span>, Rochaix P.8<\/span>, Mangel L.9<\/span>, Hermitte F.10<\/span>, Sapi Z.11<\/span>, Tornoczky T.12<\/span>, Peyrottes I.3<\/span>, Tetreau R.13<\/span>, Ch\u00e2teau M.C.13<\/span>, Sunyach M.14<\/span>, Agoston P.15<\/span>, Brisse H.2<\/span>, Le Cesne A.16<\/span>, Bonvalot S.2<\/span>
\n
\n1 \u2013 Laboratory of Integrative Cancer Immunology, INSERM, Paris, France
\n2 \u2013 Institut Curie, Paris, France
\n3 \u2013 Centre Antoine Lacassagne, Nice, France
\n4 \u2013 Institut du Cancer de Montpellier, Montpellier, France
\n5 \u2013 Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary
\n6 \u2013 Institut Claudius Regaud, IUCT-Oncopole, CRCT, Inserm, Toulouse, France
\n7 \u2013 Institut Bergoni\u00e9, Bordeaux, France
\n8 \u2013 Institut Universitaire du Cancer \u2013 Oncopole, Toulouse, France
\n9 \u2013 Pecsi Tudomanyegyetem Klinikai Kozpont, Pecsi, Hungary
\n10 \u2013 HalioDx, Marseille, France
\n11 \u2013 Semmelweis University, Budapest, Hungary
\n12 \u2013 Pecs University, Pecs, Hungary
\n13 \u2013 Centre R\u00e9gional De Lutte Contre Le Cancer Paul Lamarque Parc Eurom\u00e9decine Val d’Aurelle A, Montpellier, France
\n14 \u2013 Centre leon berad, Lyon, France
\n15 \u2013 Orsz\u00e1gos Onkol\u00f3giai Int\u00e9zet, Budapest, Hungary
\n16 \u2013 Gustave Roussy Cancer Campus, Villejuif, France
\n<\/span>[\/az_box_icons][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][\/vc_column_inner][vc_column_inner column_paddings=\u00a0\u00bb105″ column_position_vertical=\u00a0\u00bbmiddle\u00a0\u00bb module_type=\u00a0\u00bbbg-color\u00a0\u00bb animation_fx=\u00a0\u00bbyes-animation\u00a0\u00bb animation_delay=\u00a0\u00bb300″ animation_offset_scroll_down=\u00a0\u00bb90″ width=\u00a0\u00bb1\/2″ bg_color=\u00a0\u00bb#ffffff\u00a0\u00bb animation_in=\u00a0\u00bbfadeInUp\u00a0\u00bb][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][az_box_icons box_icon_title=\u00a0\u00bbSummary\u00a0\u00bb icon_visibility=\u00a0\u00bbyes-icon\u00a0\u00bb icon_type=\u00a0\u00bbfont\u00a0\u00bb icon=\u00a0\u00bbaz-icon az-icon-layers2″ icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_color=\u00a0\u00bb#28282e\u00a0\u00bb icon_size=\u00a0\u00bb50″]HfO2-NP + RT bring marked changes to the tumor immune profile both in mouse model and in patients with STS, compared to RT. So far, these results show that HfO2-NP + RT induces a specific adaptive immune pattern.<\/p>\n

In mouse, an abscopal effect was observed with HfO2-NP but not with RT alone. IHC analyses show that a significant increase of CD8+ cells is present in treated and untreated tumors, but no effect was observed for RT alone. IHC analysis (post- vs pretreatment) show a marked increase of the biomarkers for patient treated with HfO2-NP + RT, particularly for CD8+ and PD1. No differences are seen for RT alone. The profile of gene expression HfO2-NP + RT differs from RT alone. Functional analysis of genes expression up-regulated in HfO2-NP + RT shows an increase of the cytokine and immune checkpoints expression, as T cell activation markers, compared to RT alone.[\/az_box_icons][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"

The enclosed abstract was presented at the 13th Journ\u00e9es canc\u00e9ropole Grand Sud-Ouest at Poitiers. The abstract Hafnium oxide nanoparticles as an emergent promising treatment for solid tumors describes how hafnium oxide nanoparticles were designed at the nanoscale in the form of crystalline 50nm-particles to efficiently absorb ionizing radiation and increase the radiation dose deposited \u2013 \u201chot spots\u201d of energy deposit \u2013 from within the tumor cells for efficient cell killing. [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":2374,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[182,10,657],"tags":[490,488,454,198,342,200],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/1506"}],"collection":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/comments?post=1506"}],"version-history":[{"count":1,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/1506\/revisions"}],"predecessor-version":[{"id":1514,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/1506\/revisions\/1514"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/media\/2374"}],"wp:attachment":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/media?parent=1506"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/categories?post=1506"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/tags?post=1506"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}