{"id":1653,"date":"2018-10-31T07:49:33","date_gmt":"2018-10-31T07:49:33","guid":{"rendered":"http:\/\/bibliography.nanobiotix.com\/?p=1653"},"modified":"2022-05-24T16:42:57","modified_gmt":"2022-05-24T15:42:57","slug":"2018-astro-2018-nbtxr3-in-liver-cancers","status":"publish","type":"post","link":"https:\/\/bibliography.nanobiotix.com\/fr\/2018-astro-2018-nbtxr3-in-liver-cancers\/","title":{"rendered":"2018-ASTRO 2018- NBTXR3 in liver cancers"},"content":{"rendered":"

[vc_row padding_top=\u00a0\u00bb0″ padding_bottom=\u00a0\u00bb0″ section_container_layout=\u00a0\u00bbfull-width\u00a0\u00bb remove_horizontal_padding=\u00a0\u00bbyes\u00a0\u00bb module_type=\u00a0\u00bbbg-color\u00a0\u00bb gutter_size=\u00a0\u00bbyes\u00a0\u00bb equal_height=\u00a0\u00bbyes\u00a0\u00bb bg_color=\u00a0\u00bb#28282e\u00a0\u00bb][vc_column][vc_row_inner padding_top=\u00a0\u00bb0″ padding_bottom=\u00a0\u00bb0″ gutter_size=\u00a0\u00bbyes\u00a0\u00bb equal_height=\u00a0\u00bbyes\u00a0\u00bb][vc_column_inner column_paddings=\u00a0\u00bb105″ column_position_vertical=\u00a0\u00bbmiddle\u00a0\u00bb column_min_height=\u00a0\u00bb700″ column_min_height_sm=\u00a0\u00bb400″ column_min_height_xs=\u00a0\u00bb350″ module_type=\u00a0\u00bbbg-image\u00a0\u00bb bg_image=\u00a0\u00bb99″ mask_fx=\u00a0\u00bbyes-mask\u00a0\u00bb mask_color_mode=\u00a0\u00bbpalette\u00a0\u00bb mask_bg_color_palette=\u00a0\u00bbmain-mask\u00a0\u00bb animation_fx=\u00a0\u00bbyes-animation\u00a0\u00bb animation_delay=\u00a0\u00bb200″ animation_offset_scroll_down=\u00a0\u00bb90″ width=\u00a0\u00bb1\/2″ animation_in=\u00a0\u00bbfadeInUp\u00a0\u00bb][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][az_box_icons box_icon_title=\u00a0\u00bbAuthors\u00a0\u00bb box_icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_visibility=\u00a0\u00bbyes-icon\u00a0\u00bb icon_type=\u00a0\u00bbfont\u00a0\u00bb icon=\u00a0\u00bbfa fa-edit\u00a0\u00bb icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_size=\u00a0\u00bb50″ box_icon_color=\u00a0\u00bb#ffffff\u00a0\u00bb icon_color=\u00a0\u00bb#ffffff\u00a0\u00bb]E. Chajon Rodriguez1<\/span>, M. Pracht2<\/span>, T. De Baere3<\/span>, T. V. F. Nguyen4<\/span>, J. P. Bronowicki5<\/span>, V. Vendrely6<\/span>, A. S. Baumann7<\/span>, V. V. Crois\u00e9-Laurent7<\/span>, E. Rio8<\/span>, Y. Rolland9<\/span>, S. Le Sourd9<\/span>, P. Gustin3<\/span>, C. Perret10<\/span>, F. Mornex11<\/span>, D. Peiffert12<\/span>, P. Merle13<\/span>, E. Deutsch14<\/span>
\n
\n1 \u2013 Centre Eug\u00e8ne Marquis \u2013 D\u00e9partement de Radioth\u00e9rapie, Rennes, FR
\n2 \u2013 Centre Eugene Marquis, Rennes, FR
\n3 \u2013 Institut Gustave Roussy, Villejuif, FR
\n4 \u2013 Gustave Roussy, Villejuif, FR
\n5 \u2013 INSERM 954, CHU de Nancy, Universit\u00e9 de Lorraine, Nancy, FR
\n6 \u2013 University Hospital of Bordeaux, Bordeaux, FR
\n7 \u2013 Institut de Canc\u00e9rologie de Lorraine, Nancy, FR
\n8 \u2013 Institut de Canc\u00e9rologie de l\u2019Ouest, Nantes, FR
\n9 \u2013 Centre Eug\u00e8ne Marquis, Rennes, FR
\n10 \u2013 Institut de Canc\u00e9rologie de l’Ouest, Nantes, FR
\n11 \u2013 Centre Hospitalier Lyon Sud, Pierre B\u00e9nite, FR
\n12 \u2013 Institut de Canc\u00e9rologie de Lorraine, Vandoeuvre-Les-Nancy, FR
\n13 \u2013 Service d’Hepatogastroent\u00e9rologie, H\u00f4pital de la Croix Rousse, Lyon, FR
\n14 \u2013 Gustave Roussy, Universit\u00e9 Paris-Saclay, Villejuif, FR
\n<\/span>[\/az_box_icons][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][\/vc_column_inner][vc_column_inner column_paddings=\u00a0\u00bb105″ column_position_vertical=\u00a0\u00bbmiddle\u00a0\u00bb module_type=\u00a0\u00bbbg-color\u00a0\u00bb animation_fx=\u00a0\u00bbyes-animation\u00a0\u00bb animation_delay=\u00a0\u00bb300″ animation_offset_scroll_down=\u00a0\u00bb90″ width=\u00a0\u00bb1\/2″ bg_color=\u00a0\u00bb#ffffff\u00a0\u00bb animation_in=\u00a0\u00bbfadeInUp\u00a0\u00bb][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][az_box_icons box_icon_title=\u00a0\u00bbSummary\u00a0\u00bb icon_visibility=\u00a0\u00bbyes-icon\u00a0\u00bb icon_type=\u00a0\u00bbfont\u00a0\u00bb icon=\u00a0\u00bbaz-icon az-icon-layers2″ icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_color=\u00a0\u00bb#28282e\u00a0\u00bb icon_size=\u00a0\u00bb50″]Radiation oncology technological development is principally focused in improving the precision of radiotherapy (RT) and reducing unwanted irradiation to normal tissues. There is an unmet medical need into ameliorating the energy dose deposit within tumor cells without increasing the dose received by surrounding healthy tissues. In response, hafnium oxide nanoparticles, NBTXR3, were developed. Only when activated by RT, NBTXR3 increases the probability of interaction with incoming radiations to augment the energy dose deposition within tumor cells leading to their death.<\/p>\n

Their use is particularly relevant in the management of liver cancers, notably hepatocellular carcinoma (HCC) and liver metastasis (mets). This population is heterogenous and difficult to treat due to the presence of underlying liver dysfunction and concomitant malignancies.<\/p>\n

NBTXR3 activated by stereotactic body radiotherapy (SBRT) is currently evaluated in this population in a phase I\/II study [NCT02721056]. The multidisciplinary aspect of the study, emphasized by the plurality of liver affections, leads physicians from multiple backgrounds to combine their expertise in managing patient\u2019s course.<\/p>\n

NBTXR3 was well tolerated and comes with a promising safety profile. Recruitment of dose level 22% is ongoing. This study successfully demonstrated the feasibility of a complex multidisciplinary coordination for 2 different important indications in liver oncology.[\/az_box_icons][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"

Radiation oncology technological development is principally focused in improving the precision of radiotherapy (RT) and reducing unwanted irradiation to normal tissues. There is an unmet medical need into ameliorating the energy dose deposit within tumor cells without increasing the dose received by surrounding healthy tissues. [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":1625,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[182,183,669],"tags":[491,463,342,483],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/1653"}],"collection":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/comments?post=1653"}],"version-history":[{"count":1,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/1653\/revisions"}],"predecessor-version":[{"id":1654,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/1653\/revisions\/1654"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/media\/1625"}],"wp:attachment":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/media?parent=1653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/categories?post=1653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/tags?post=1653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}