{"id":1694,"date":"2018-10-31T15:13:09","date_gmt":"2018-10-31T15:13:09","guid":{"rendered":"http:\/\/bibliography.nanobiotix.com\/2018-astro-nbtxr3-anti-tumor-immune-response\/"},"modified":"2022-05-24T17:10:39","modified_gmt":"2022-05-24T16:10:39","slug":"2018-astro-nbtxr3-anti-tumor-immune-response","status":"publish","type":"post","link":"https:\/\/bibliography.nanobiotix.com\/fr\/2018-astro-nbtxr3-anti-tumor-immune-response\/","title":{"rendered":"2018 \u2013 ASTRO \u2013 NBTXR3 Anti-Tumor Immune Response"},"content":{"rendered":"

[vc_row padding_top=\u00a0\u00bb0″ padding_bottom=\u00a0\u00bb0″ section_container_layout=\u00a0\u00bbfull-width\u00a0\u00bb remove_horizontal_padding=\u00a0\u00bbyes\u00a0\u00bb module_type=\u00a0\u00bbbg-color\u00a0\u00bb gutter_size=\u00a0\u00bbyes\u00a0\u00bb equal_height=\u00a0\u00bbyes\u00a0\u00bb bg_color=\u00a0\u00bb#28282e\u00a0\u00bb][vc_column][vc_row_inner padding_top=\u00a0\u00bb0″ padding_bottom=\u00a0\u00bb0″ gutter_size=\u00a0\u00bbyes\u00a0\u00bb equal_height=\u00a0\u00bbyes\u00a0\u00bb][vc_column_inner column_paddings=\u00a0\u00bb105″ column_position_vertical=\u00a0\u00bbmiddle\u00a0\u00bb column_min_height=\u00a0\u00bb700″ column_min_height_sm=\u00a0\u00bb400″ column_min_height_xs=\u00a0\u00bb350″ module_type=\u00a0\u00bbbg-image\u00a0\u00bb bg_image=\u00a0\u00bb99″ mask_fx=\u00a0\u00bbyes-mask\u00a0\u00bb mask_color_mode=\u00a0\u00bbpalette\u00a0\u00bb mask_bg_color_palette=\u00a0\u00bbmain-mask\u00a0\u00bb animation_fx=\u00a0\u00bbyes-animation\u00a0\u00bb animation_delay=\u00a0\u00bb200″ animation_offset_scroll_down=\u00a0\u00bb90″ width=\u00a0\u00bb1\/2″ animation_in=\u00a0\u00bbfadeInUp\u00a0\u00bb][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][az_box_icons box_icon_title=\u00a0\u00bbAuthors\u00a0\u00bb box_icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_visibility=\u00a0\u00bbyes-icon\u00a0\u00bb icon_type=\u00a0\u00bbfont\u00a0\u00bb icon=\u00a0\u00bbfa fa-edit\u00a0\u00bb icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_size=\u00a0\u00bb50″ box_icon_color=\u00a0\u00bb#ffffff\u00a0\u00bb icon_color=\u00a0\u00bb#ffffff\u00a0\u00bb]Galon J.1<\/span>, La\u00e9 M.2<\/span>, Thariat J.3<\/span>, Carrere S.4<\/span>, Papai Z.5<\/span>, Delannes M.6<\/span>, Sargos P.7<\/span>, Rochaix P.6<\/span>, Mangel L. C.8<\/span>, Sapi Z.9<\/span>, Tornoczky T.8<\/span>, Peyrottes I.10<\/span>, Tetreau R.11<\/span>, Ch\u00e2teau M. C.4<\/span>, Sunyach M. P.12<\/span>, Agoston P.13<\/span>, Brisse H.2<\/span>, Llacer C.11<\/span>, Lecesne A.14<\/span>, Bonvalot S.2<\/span>
\n
\n1 \u2013 INSERM, Paris, France
\n2 \u2013 Institut Curie, Paris, France
\n3 \u2013 Centre Baclesse, Caen, France
\n4 \u2013 Institut du cancer de Montpellier, Montpellier, France
\n5 \u2013 Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary
\n6 \u2013 Institut Universitaire du Cancer Toulouse, Toulouse, France
\n7 \u2013 Department of Radiation Oncology, Institut Bergonie, Bordeaux, France
\n8 \u2013 Pecs University, Pecs, Hungary
\n9 \u2013 Semmelweis University, Budapest, Hungary
\n10 \u2013 Centre Antoine Lacassagne, Nice, France
\n11 \u2013 Montpellier Cancer Institute, Montpellier, France
\n12 \u2013 Centre L\u00e9on Berard, Lyon, France
\n13 \u2013 National Institute of Oncology, Budapest, Hungary
\n14 \u2013 Institut Gustave Roussy, Villejuif, France
\n<\/span>[\/az_box_icons][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][\/vc_column_inner][vc_column_inner column_paddings=\u00a0\u00bb105″ column_position_vertical=\u00a0\u00bbmiddle\u00a0\u00bb module_type=\u00a0\u00bbbg-color\u00a0\u00bb animation_fx=\u00a0\u00bbyes-animation\u00a0\u00bb animation_delay=\u00a0\u00bb300″ animation_offset_scroll_down=\u00a0\u00bb90″ width=\u00a0\u00bb1\/2″ bg_color=\u00a0\u00bb#ffffff\u00a0\u00bb animation_in=\u00a0\u00bbfadeInUp\u00a0\u00bb][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][az_box_icons box_icon_title=\u00a0\u00bbSummary\u00a0\u00bb icon_visibility=\u00a0\u00bbyes-icon\u00a0\u00bb icon_type=\u00a0\u00bbfont\u00a0\u00bb icon=\u00a0\u00bbaz-icon az-icon-layers2″ icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_color=\u00a0\u00bb#28282e\u00a0\u00bb icon_size=\u00a0\u00bb50″]Soft tissue sarcoma<\/em> (STS<\/em>) is a rare type of cancer, which occurs in tissues connecting, supporting and\/or surrounding other structures of the body, like muscle, fat, etc. More than 50 subtypes of STS<\/em> exist, characterized by a strong propensity to local recurrence and metastatic spreading. Consistently, the immune microenvironment in sarcomas is highly variable. A new class of high electron density material, hafnium oxide, was designed at the nanoscale to efficiently absorb ionizing radiation from within the tumor cells and increase the dose deposition into the tumor.<\/p>\n

These nanoparticles (HfO2-NP), delivered into the tumor by a single injection and activated by radiotherapy, have the ability to enhance immunogenic cell death and immune response in preclinical studies. Here, we explore in a phase II\/III trial in patients with locally advanced STS, the effects of nanosized hafnium oxide exposed to RT in terms of tumor immune profile changes in patients, when compared to RT alone.<\/p>\n

Regarding immune cells infiltrates (post- vs pre-treatment), promising results are reported for patients treated with HfO2-NP activated by RT, when compared to RT. So far, these results show that HfO2-NP + RT induces a specific adaptive immune pattern. As such, it may convert immunologically \u201ccold\u201d tumor into \u201chot\u201d tumor and be effectively combined with immunotherapeutic agents across oncology. More tissue samples are under evaluation to reinforce these findings.[\/az_box_icons][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"

Soft tissue sarcoma (STS) is a rare type of cancer, which occurs in tissues connecting, supporting and\/or surrounding other structures of the body, like muscle, fat, etc. More than 50 subtypes of STS exist, characterized by a strong propensity to local recurrence and metastatic spreading. Consistently, the immune microenvironment in sarcomas is highly variable. A new class of high electron density material, hafnium oxide, was designed at the nanoscale to efficiently absorb ionizing radiation from within the tumor cells and increase the dose deposition into the tumor. [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":1686,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[182,183,674],"tags":[454,342,334,513],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/1694"}],"collection":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/comments?post=1694"}],"version-history":[{"count":0,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/1694\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/media\/1686"}],"wp:attachment":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/media?parent=1694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/categories?post=1694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/tags?post=1694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}