{"id":2454,"date":"2022-05-12T13:19:22","date_gmt":"2022-05-12T12:19:22","guid":{"rendered":"https:\/\/bibliography.nanobiotix.com\/?p=2454"},"modified":"2022-06-01T16:11:53","modified_gmt":"2022-06-01T15:11:53","slug":"2020-review-of-clinical-application-of-radiation-enhancing-nanoparticles","status":"publish","type":"post","link":"https:\/\/bibliography.nanobiotix.com\/fr\/2020-review-of-clinical-application-of-radiation-enhancing-nanoparticles\/","title":{"rendered":"2020 \u2013 Review of Clinical Application of Radiation Enhancing Nanoparticles"},"content":{"rendered":"<section class=\"wpb-content-wrapper\"><p>[vc_row padding_top=\u00a0\u00bb0&Prime; padding_bottom=\u00a0\u00bb0&Prime; section_container_layout=\u00a0\u00bbfull-width\u00a0\u00bb remove_horizontal_padding=\u00a0\u00bbyes\u00a0\u00bb module_type=\u00a0\u00bbbg-color\u00a0\u00bb gutter_size=\u00a0\u00bbyes\u00a0\u00bb equal_height=\u00a0\u00bbyes\u00a0\u00bb bg_color=\u00a0\u00bb#28282e\u00a0\u00bb][vc_column][vc_row_inner padding_top=\u00a0\u00bb0&Prime; padding_bottom=\u00a0\u00bb0&Prime; gutter_size=\u00a0\u00bbyes\u00a0\u00bb equal_height=\u00a0\u00bbyes\u00a0\u00bb][vc_column_inner column_paddings=\u00a0\u00bb105&Prime; column_position_vertical=\u00a0\u00bbmiddle\u00a0\u00bb column_min_height=\u00a0\u00bb700&Prime; column_min_height_sm=\u00a0\u00bb400&Prime; column_min_height_xs=\u00a0\u00bb350&Prime; module_type=\u00a0\u00bbbg-image\u00a0\u00bb bg_image=\u00a0\u00bb99&Prime; mask_fx=\u00a0\u00bbyes-mask\u00a0\u00bb mask_color_mode=\u00a0\u00bbpalette\u00a0\u00bb mask_bg_color_palette=\u00a0\u00bbmain-mask\u00a0\u00bb animation_fx=\u00a0\u00bbyes-animation\u00a0\u00bb animation_delay=\u00a0\u00bb200&Prime; animation_offset_scroll_down=\u00a0\u00bb90&Prime; width=\u00a0\u00bb1\/2&Prime; animation_in=\u00a0\u00bbfadeInUp\u00a0\u00bb][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][az_box_icons box_icon_title=\u00a0\u00bbAuthors\u00a0\u00bb box_icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_visibility=\u00a0\u00bbyes-icon\u00a0\u00bb icon_type=\u00a0\u00bbfont\u00a0\u00bb icon=\u00a0\u00bbfa fa-edit\u00a0\u00bb icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_size=\u00a0\u00bb50&Prime; box_icon_color=\u00a0\u00bb#ffffff\u00a0\u00bb icon_color=\u00a0\u00bb#ffffff\u00a0\u00bb]N Scher<span class=\"notes up\">1<\/span>, S Bonvalot<span class=\"notes up\">2<\/span>, C Le Tourneau<span class=\"notes up\">3,4,5<\/span>, E Chajon<span class=\"notes up\">6<\/span>, C Verry<span class=\"notes up\">7,8<\/span>, J Thariat<span class=\"notes up\">9<\/span>, V Calugaru<span class=\"notes up\">1<\/span><br \/>\n<span class=\"notes\"><br \/>\n1 \u2013 Department of Radiation Oncology, Institut Curie, Paris, France<br \/>\n2 \u2013 Department of Surgery, PSL University, Institute Curie, Paris, France<br \/>\n3 \u2013 Department of Drug Development and Innovation (D3i), Institut Curie, Paris &amp; Saint-Cloud, France<br \/>\n4 \u2013 INSERM U900 Research Unit, Saint-Cloud, France<br \/>\n5 \u2013 Paris-Saclay University, Paris, France<br \/>\n6 \u2013 Department of Radiotherapy. Eug\u00e8ne Marquis Cancer Center, Rennes, France<br \/>\n7 \u2013 Grenoble Alpes University Hospital, Department of Radiotherapy 38043 Grenoble, France<br \/>\n8 \u2013 Rayonnement Synchrotron Pour la Recherche M\u00e9dicale (STROBE), Universit\u00e9 Grenoble Alpes, Inserm UA7, 71 Rue des Martyrs, 38000 Grenoble, France<br \/>\n9 \u2013 Department of Radiotherapy, Fran\u00e7ois Baclesse Centre, 3 Rue Du G\u00e9n\u00e9ral Harris, 14000, Caen, France<br \/>\n<\/span>[\/az_box_icons][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][\/vc_column_inner][vc_column_inner column_paddings=\u00a0\u00bb105&Prime; column_position_vertical=\u00a0\u00bbmiddle\u00a0\u00bb module_type=\u00a0\u00bbbg-color\u00a0\u00bb animation_fx=\u00a0\u00bbyes-animation\u00a0\u00bb animation_delay=\u00a0\u00bb300&Prime; animation_offset_scroll_down=\u00a0\u00bb90&Prime; width=\u00a0\u00bb1\/2&Prime; bg_color=\u00a0\u00bb#ffffff\u00a0\u00bb animation_in=\u00a0\u00bbfadeInUp\u00a0\u00bb][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][az_box_icons box_icon_title=\u00a0\u00bbSummary\u00a0\u00bb icon_visibility=\u00a0\u00bbyes-icon\u00a0\u00bb icon_type=\u00a0\u00bbfont\u00a0\u00bb icon=\u00a0\u00bbaz-icon az-icon-layers2&Prime; icon_color_mode=\u00a0\u00bbon-the-fly\u00a0\u00bb icon_color=\u00a0\u00bb#28282e\u00a0\u00bb icon_size=\u00a0\u00bb50&Prime;]<strong>Purpose:<\/strong> Clinical evidence of the radiation-enhancing effects of nanoparticles has emerged.<\/p>\n<p><strong>Materials and methods:<\/strong> We searched the literature in English and French on PubMed up to October 2019. The search term was \u00ab\u00a0nanoparticle\u00a0\u00bb AND \u00ab\u00a0radiotherapy\u00a0\u00bb, yielding 1270 results.<br \/>\nResults: The two main NP used in clinical trials were hafnium oxide and gadolinium involving a total of 229 patients. Hafnium oxide NP were used in three phase 1\/2 trials on sarcoma, head and neck squamous cell carcinoma or liver cancer and one phase 2\/3 trial. There are six ongoing phase 1\/2 clinical trials to evaluate the combination of gadolinium-based NP and RT for the treatment of brain metastases and cervical cancer.<\/p>\n<p><strong>Conclusion:<\/strong> So far, intratumoral hafnium oxide nanoparticles were safe and improved efficacy in locally advanced sarcoma.[\/az_box_icons][vc_empty_space height=\u00a0\u00bb60px\u00a0\u00bb responsive_lg=\u00a0\u00bbhidden\u00a0\u00bb responsive_md=\u00a0\u00bbhidden\u00a0\u00bb][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>The two main NP used in clinical trials were hafnium oxide and gadolinium involving a total of 229 patients. Hafnium oxide NP were used in three phase 1\/2 trials on sarcoma, head and neck squamous cell carcinoma or liver cancer and one phase 2\/3 trial. There are six ongoing phase 1\/2 clinical trials to evaluate the combination of gadolinium-based NP and RT for the treatment of brain metastases and cervical cancer. [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":2458,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[8,675,676,7,186],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/2454"}],"collection":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/comments?post=2454"}],"version-history":[{"count":2,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/2454\/revisions"}],"predecessor-version":[{"id":2461,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/posts\/2454\/revisions\/2461"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/media\/2458"}],"wp:attachment":[{"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/media?parent=2454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/categories?post=2454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bibliography.nanobiotix.com\/fr\/wp-json\/wp\/v2\/tags?post=2454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}