Delivery | Nano Publications https://bibliography.nanobiotix.com Navigate through all Nanobiotix publications online Wed, 25 May 2022 09:23:41 +0000 en-US hourly 1 https://wordpress.org/?v=6.0 https://bibliography.nanobiotix.com/wp-content/uploads/2019/11/cropped-n-icon-512x512-32x32.png Delivery | Nano Publications https://bibliography.nanobiotix.com 32 32 2011 – CLINAM Abstract – Thermosensitive Magnetoliposomes for MRI-Guided Drug Delivery – Meyr et al. https://bibliography.nanobiotix.com/2011-clinam-abstract-thermosensitive-magnetoliposomes-for-mri-guided-drug-delivery-meyr-et-al/ https://bibliography.nanobiotix.com/2011-clinam-abstract-thermosensitive-magnetoliposomes-for-mri-guided-drug-delivery-meyr-et-al/#respond Tue, 07 Feb 2017 17:06:16 +0000 http://localhost:8888/nano-publications/?p=241 Congress: CLINAM, 23rd May 2011 – The development of new activatable drug nanocarriers, with multiple functionalities, presents a promising approach for cancer treatment. Improved drug delivery and controlled drug release at the tumor site may have considerable benefit by increasing treatment efficacy while reducing side effects and toxicity. Further, the possibility to monitor both nanocarrier accumulation and drug release via current clinical imaging techniques may be particularly relevant for an optimal treatment.

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Authors

Marie-Edith Meyre1, Cyril Lorenzato2, Matthieu Germain1, Pierre Smirnov2, Chrit Moonen2, Agnès Pottier1 and Laurent Levy1
1 – Nanobiotix, Paris, France
2 – Laboratoire Imagerie Moléculaire et Fonctionnelle. UMR 5231 CNRS / Université Bordeaux 2. France

Summary

Congress: CLINAM, 23rd May 2011

Contents: The development of new activatable drug nanocarriers, with multiple functionalities, presents a promising approach for cancer treatment.

Improved drug delivery and controlled drug release at the tumor site may have considerable benefit by increasing treatment efficacy while reducing side effects and toxicity. Further, the possibility to monitor both nanocarrier accumulation and drug release via current clinical imaging techniques may be particularly relevant for an optimal treatment.

Within the European project “Sonodrugs”, we investigated the opportunity of triggering the drug release from new nanocarriers (temperature and pressure-sensitive) thanks to High Intensity Focused Ultrasounds (HIFU) and monitoring the release profile of the drug at the tumor site thanks to Magnetic Resonance Imaging (MRI) imaging.

A new versatile thermosensitive liposome has been designed and developed to efficiently encapsulate a drug (doxorubicin) and a contrast agent (superparamagnetic iron oxide nanoparticles).

The post 2011 – CLINAM Abstract – Thermosensitive Magnetoliposomes for MRI-Guided Drug Delivery – Meyr et al. first appeared on Nano Publications.]]> https://bibliography.nanobiotix.com/2011-clinam-abstract-thermosensitive-magnetoliposomes-for-mri-guided-drug-delivery-meyr-et-al/feed/ 0 2010 – Combinations of proteins with Nano-Systems – Di Marco et al. https://bibliography.nanobiotix.com/2010-combinations-of-proteins-with-nano-systems-di-marco-et-al/ https://bibliography.nanobiotix.com/2010-combinations-of-proteins-with-nano-systems-di-marco-et-al/#respond Mon, 06 Feb 2017 12:30:17 +0000 http://localhost:8888/nano-publications/?p=132 The latest development of protein engineering allows the production of proteins having desired properties and large potential markets, but the clinical advances of therapeutical proteins are still limited by their fragility. Nanotechnology could provide optimal vectors able to protect from degradation therapeutical biomolecules such as proteins, enzymes or specific polypeptides.

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Authors

Mariagrazia Di Marco1, Shaharum Shamsuddin2, Khairunisak Abdul Razak3, Azlan Abdul Aziz4, Corinne Devaux1, Elsa Borghi1, Laurent Levy1, Claudia Sadun5
1 – Nanobiotix, Paris, France
2 – School of Health Sciences, Health Campus Universiti Sains Malaysia, Kelantan, Malaysia
3 – School of Materials and Mineral Resources Engineering, Engineering Campus
4 – School of Physics, Universiti Sains Malaysia, Penang, Malaysia
5 – Department of Chemistry, Sapienza, University of Rome, Rome, Italy

Summary

Abstract: The latest development of protein engineering allows the production of proteins having desired properties and large potential markets, but the clinical advances of therapeutical proteins are still limited by their fragility. Nanotechnology could provide optimal vectors able to protect from degradation therapeutical biomolecules such as proteins, enzymes or specific polypeptides.

On the other hand, some proteins can be also used as active ligands to help nanoparticles loaded with chemotherapeutic or other drugs to reach particular sites in the body. The aim of this review is to provide an overall picture of the general aspects of the most successful approaches used to combine proteins with nanosystems. This combination is mainly achieved by absorption, bioconjugation and encapsulation. Interactions of nanoparticles with biomolecules and caveats related to protein denaturation are also pointed out. A clear understanding of nanoparticle-protein interactions could make possible the design of precise and versatile hybrid nanosystems. This could further allow control of their pharmacokinetics as well as activity, and safety.

Keywords: nanoparticles, drug delivery, proteins, polypeptides, absorption, bioconjugation, encapsulation

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