Monte Carlo Calculation | Nano Publications https://bibliography.nanobiotix.com Navigate through all Nanobiotix publications online Tue, 24 May 2022 15:50:43 +0000 en-US hourly 1 https://wordpress.org/?v=6.0 https://bibliography.nanobiotix.com/wp-content/uploads/2019/11/cropped-n-icon-512x512-32x32.png Monte Carlo Calculation | Nano Publications https://bibliography.nanobiotix.com 32 32 2017 – Abstract – 13th Journées cancéropole GSO – HfO2 nanoparticles in solid tumors https://bibliography.nanobiotix.com/2017-abstract-13th-journees-canceropole-gso-hfo2-nanoparticles-in-solid-tumors/ https://bibliography.nanobiotix.com/2017-abstract-13th-journees-canceropole-gso-hfo2-nanoparticles-in-solid-tumors/#respond Wed, 02 May 2018 14:11:59 +0000 http://bibliography.nanobiotix.com/?p=1376 The enclosed abstract was presented at the 13th Journées cancéropole Grand Sud-Ouest at Poitiers. The abstract Hafnium oxide nanoparticles as an emergent promising treatment for solid tumors describes how hafnium oxide nanoparticles were designed at the nanoscale in the form of crystalline 50nm-particles to efficiently absorb ionizing radiation and increase the radiation dose deposited – “hot spots” of energy deposit – from within the tumor cells for efficient cell killing. […]

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Authors

M. Dimitriu1, A. Pottier1, C. Le Tourneau2, P. Sargos3, Le Pechoux4, G. Kantor3, T. De Baere4, A. Le Cesne4, V. Moreno5, E. Calvo5, S. Bonvalot2

1 – Nanobiotix, Paris, France
2 – Institut Curie, Paris, France
3 – Institut Bergonié, Bordeaux, France
4 – Institut Gustave Roussy, Villejuif, France
5 – START Madrid, Spain

Summary

The enclosed abstract was presented at the 13th Journées cancéropole Grand Sud-Ouest at Poitiers. The abstract Hafnium oxide nanoparticles as an emergent promising treatment for solid tumors describes how hafnium oxide nanoparticles were designed at the nanoscale in the form of crystalline 50nm-particles to efficiently absorb ionizing radiation and increase the radiation dose deposited – “hot spots” of energy deposit – from within the tumor cells for efficient cell killing.

Hafnium oxide nanoparticles (NBTXR3), administered as a single intratumoral injection and activated by radiotherapy, is currently evaluated in a phase II/III clinical trial in soft tissue sarcoma (STS) [NCT02379845], and in phase I/II clinical trials for head and neck [NCT01946867], prostate [NCT02805894], liver [NCT02721056; NCT02721056] and rectum cancers [NCT02465593]. So far, patients treated with NBTXR3 received radiotherapy as planned and showed a very good local safety profile.

The post 2017 – Abstract – 13th Journées cancéropole GSO – HfO2 nanoparticles in solid tumors first appeared on Nano Publications.]]> https://bibliography.nanobiotix.com/2017-abstract-13th-journees-canceropole-gso-hfo2-nanoparticles-in-solid-tumors/feed/ 0 2017 – AACR-EORTC-NCI Monte Carlo Calculation https://bibliography.nanobiotix.com/2017-aacr-eortc-nci-monte-carlo-calculation/ https://bibliography.nanobiotix.com/2017-aacr-eortc-nci-monte-carlo-calculation/#respond Thu, 09 Nov 2017 07:20:09 +0000 http://bibliography.nanobiotix.com/?p=1289 Today, more than half of all cancer patients receive radiotherapy as part of their treatment. However, radiotherapy efficacy is often limited by healthy tissues toxicity and needs to be optimized. One relevant solution is to increase the radiation dose deposition from within the tumor cells. […]

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Authors

Agnès Pottier1, Elsa Borghi1, Balder Villagomez-Bernabe2, Fred Currell2

1 – Nanobiotix, Paris, France
2 – Queen’s University, Belfast, United Kingdom

Summary

Today, more than half of all cancer patients receive radiotherapy as part of their treatment. However, radiotherapy efficacy is often limited by healthy tissues toxicity and needs to be optimized. One relevant solution is to increase the radiation dose deposition from within the tumor cells. The presence of high atomic number (high-Z) elements within the X-ray pathway increases the probability of interaction with ionizing radiation as compared with tissues (composed of low-Z elements). Likewise, mammalian cells can handle materials at the nanoscale. Therefore, materials made of high-Z elements designed at the nanoscale can enhance the deposit of the radiation dose at the cancer cell level.

Still, the most relevant design of these nano-objects has been scarcely explored. Here, we hypothesize that the packing of high-Z elements within the nano-object is a key parameter when considering its design. We used gold and probe how its packing at the nanoscale can achieve the best probability of interaction with ionizing radiation. […]

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