NBTXR3 hafnium oxide nanoparticle activated by ionizing radiation

AACR · 2011, Maggiorella L. et al.

Nano Publications > Congress Abstracts > In Vitro in Vivo NBTXR3 > In Vitro > 2011 – AACR Abstract – NBTXR3 radioenhancement and anti-tumor effect in vitro – Magiorella et al.

Authors

Maggiorella Laurence1, Darmon Audrey1, Sonia Vivet1, Zhang Ping1, Polrot Melanie2, Deutsch Eric3, Bourhis Jean3, Pottier Agnes1, Borghi Elsa1, Levy Laurent1
1 – Nanobiotix, 60 rue de Wattignies 75012 Paris
2 – Institut Gustave Roussy, IRCV, 114 rue Edouard Vaillant, 94805 Villejuif Cedex
3 – Institut Gustave Roussy, Laboratoire UPRES EA 27-10, Radiosensibilité des tumeurs et tissus sains,
114 rue Edouard Vaillant, 94805 Villejuif Cedex

Summary

Full Title: NBTXR3 hafnium oxide nanoparticle activated by ionizing radiation demonstrates marked radioenhancement and antitumor effect via high energy deposit in human soft tissue sarcoma

Content: Local and systemic control of Soft Tissue Sarcoma (STS) remains a clinical challenge. Radiation therapy is part of the standard of care of STS. The narrowness of its therapeutic window represents the main concern for different clinical settings. Thus, local delivery of radiation doses is critical to ensure optimal benefit-risk ratio. NBTXR3, biocompatible hafnium oxide nanoparticles were designed as therapeutics to be activated by ionizing radiation to achieve tumor control by enhancement of local energy deposition.

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