NBTXR3 has been evaluated in numerous in vivo models. The antitumor efficacy was systematically enhanced in terms of tumor growth delay for animals treated with NBTXR3 and exposed to radiotherapy when compared to radiotherapy alone. In this abstract the transferability of the treatment with NBTXR3 from one type of cancer to the other is described. NBTXR3 is intended to be injected in the tumors. Spilling in the circulation may occur during product administration or, as expected, during tumor destruction, leading to steady trapping of NPs in the reticulo-endothelial system (liver and spleen). Clinically, it is unknown whether patients, previously treated with NPs, may show toxic signs when NPs are exposed (activation) to diagnosis imaging (computed tomography(CT)) of the liver.
Nanotechnology offers revolutionary strategies to improve healthcare. Adequate nanomaterial characterization constitutes the basis to establish relevant programs of nanoparticle/biological systems cross talk evaluation. Also, the surrounding conditions significantly impact on the state of the nanoparticles in terms of their collective behavior: dispersion, aggregation, and stability in gas or liquid.