Publications | Nano Publications

2012 – Efficacy of NBTXR3 in vitro and in vivo – Maggiorella et al.

In Vitro, In Vitro in Vivo NBTXR3, In Vivo, NO-RIGHTS, Publications

There is considerable interest in approaches that could improve the therapeutic window of radiotherapy. In this study, hafnium oxide nanoparticles were designed that concentrate in tumor cells to achieve intracellular highenergy dose deposit. Materials & methods: Conventional methods were used, implemented in different ways, to explore interactions of these high-atomicnumber nanoparticles and ionizing radiation with biological systems.

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2010 – Concept of NBTXR3 – Borghi et al.

Divers, NO-RIGHTS, NO-RIGHTS, Publications, Publications

La nanotechnologie permet une gestion et un assemblage de matériaux sans précédent dans l’histoire des produits utilisés en santé humaine. Cette révolution est apportée par la possibilité d’utiliser de nouveaux mécanismes thérapeutiques et de dissocier les différentes fonctions de la substance médicamenteuse (distribution, effet thérapeutique…), ce qui était jusqu’ici impossible avec les médicaments classiques.

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2010 – Nanocarrier for Photodynamic Therapy – Thienot et al.

Divers, NO-RIGHTS, Publications

A new versatile hybrid nano carrier has been designed using a “soft chemistry” synthesis, to efficiently encapsulate a photosensitizer – the protoporphyrin IX (Pp IX) – while preserving its activity intact in biological environment for advantageous use in photodynamic therapy (PDT).

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2010 – Silica Nanoparticles – Simon et al.

Divers, NO-RIGHTS, Publications

Protoporphyrin IX (Pp IX) silica nanoparticles, developed for effective use in photodynamic therapy (PDT), were explored in in vitro and in vivo models with the ambition to improve knowledge on the role of biological factors in the photodamage. Pp IX silica nanoparticles are found efficient at temperature with extreme metabolic downregulation, which suggest a high proportion of passive internalization. For the first time, clearance of silica nanoparticles on tumor cells is established. Cell viability assessment in six tumor cell lines is reported.

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2010 – Combinations of proteins with Nano-Systems – Di Marco et al.

Divers, NO-RIGHTS, Publications

The latest development of protein engineering allows the production of proteins having desired properties and large potential markets, but the clinical advances of therapeutical proteins are still limited by their fragility. Nanotechnology could provide optimal vectors able to protect from degradation therapeutical biomolecules such as proteins, enzymes or specific polypeptides.

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